Surgical Neurology
Volume 65, Issue 1 , Pages 11-17 , January 2006

Intracranial hemangiopericytomas: correlation of topoisomerase IIα expression with biologic behavior

  • Geeta Chacko, MD

      Affiliations

    • Division of Neuropathology, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore 632004, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 416 2282185, 2282018; fax: +91 416 2232035, 2232103.
    • ,
  • Ari G. Chacko, MCh

      Affiliations

    • Division of Neurosurgery, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore 632004, India
    • ,
  • Vedantam Rajshekhar, MCh

      Affiliations

    • Division of Neurosurgery, Department of Neurological Sciences, Christian Medical College and Hospital, Vellore 632004, India
    • ,
  • Jayaprakash P. Muliyil, MD

      Affiliations

    • Department of Community Health, Christian Medical College and Hospital, Vellore 632004, India

Received 25 January 2005 ,Accepted 3 August 2005.

  • Image Result

    Hemangiopericytoma. A: Illustrating high cellularity and staghorn configuration of blood vessels (hematoxylin-eosin stain, magnification ×90). B: Dense perivascular and pericellular reticulin (Gordon

    Hemangiopericytoma. A: Illustrating high cellularity and staghorn configuration of blood vessels (hematoxylin-eosin stain, magnification ×90). B: Dense perivascular and pericellular reticulin (Gordon and Sweet reticulin stain, magnification ×400). C: Cytoplasmic immunopositivity with vimentin (streptavidin-biotin-peroxidase, magnification ×400). D: Immunopositivity of blood vessels for CD34 (streptavidin-biotin-peroxidase, magnification ×90). E: Topoisomerase IIα index of less than 5% (streptavidin-biotin-peroxidase, magnification ×400). F: Topoisomerase IIα index of 5% or greater (streptavidin-biotin-peroxidase, magnification ×400).

  • Image Result
    A: Incidence of recurrence in relation to mitotic index. B: Incidence of recurrence in relation to TPI.

    A: Incidence of recurrence in relation to mitotic index. B: Incidence of recurrence in relation to TPI.

  • Image Result
    Relation of mitotic index to TPI.

    Relation of mitotic index to TPI.

  • Image Result
    Relation of radiotherapy to incidence of recurrence.

    Relation of radiotherapy to incidence of recurrence.

  • Image Result
    Kaplan-Meier plot: overall recurrence-free rates.

    Kaplan-Meier plot: overall recurrence-free rates.

  • Image Result
    Recurrence-free rates at 5 years for select variables (survival analysis). RT indicates radiation therapy.

    Recurrence-free rates at 5 years for select variables (survival analysis). RT indicates radiation therapy.

PII: S0090-3019(05)00611-7

doi: 10.1016/j.surneu.2005.08.013

Surgical Neurology
Volume 65, Issue 1 , Pages 11-17 , January 2006

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