Surgical Neurology
Volume 72, Issue 3 , Pages 205-214 , September 2009

Cell phones and brain tumors: a review including the long-term epidemiologic data

  • Vini G. Khurana, PhD, FRACS

      Affiliations

    • Australian National University, Australia
    • Department of Neurosurgery, The Canberra Hospital, Garran ACT 2605, Australia
    • Corresponding Author InformationCorresponding author. Department of Neurosurgery, The Canberra Hospital, Garran ACT 2605, Australia. Tel.: +61 2 6244 3937; fax: +61 2 6244 2718.
  • ,
  • Charles Teo, MBBS, FRACS

      Affiliations

    • The Prince of Wales Private Hospital, Randwick NSW 2031, Australia
  • ,
  • Michael Kundi, PhD

      Affiliations

    • Institute of Environmental Health, Medical University of Vienna, Vienna A-1095, Austria
  • ,
  • Lennart Hardell, MD, PhD

      Affiliations

    • Department of Oncology, University Hospital, Orebro SE-701 85, Sweden
  • ,
  • Michael Carlberg, MSc

      Affiliations

    • Department of Oncology, University Hospital, Orebro SE-701 85, Sweden

Received 23 December 2008 ,Accepted 21 January 2009.

References 

  1. Bethke L, Webb E, Murray A, et al. Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma. Hum Mol Genet. 2008;17:800–805
  2. BioInitiative Working Group. In:  Sage C,  Carpenter DO editor. BioInitiative report: a rationale for a biologically-based public exposure standard for electromagnetic fields (ELF and RF); 2007. 2008;http://www.bioinitiative.org
  3. Cardis E, Deltour I, Mann S, et al. Distribution of RF energy emitted by mobile phones in anatomical structures of the brain. Phys Med Biol. 2008;53:2771–2783
  4. Cardis E, Richardson L, Deltour I, et al. The INTERPHONE study: design, epidemiological methods, and description of the study population. Eur J Epidemiol. 2007;22:647–664
  5. Carlo GL, Jenrow RS. Scientific progress—wireless phones and brain cancer: current state of the science. MedGenMed. 2000;2:E40
  6. CBTRUS . Statistical reports (2002-3, 2004-5, 2005-6, 2007-8). Primary brain tumors in the United States, 1995-2004 (years of data collected in sequential reports). Central Brain Tumor Registry of the United States. http://cbtrus.org/reports/reports.html
  7. Chou CK, Guy AW, Kunz LL, et al. Long-term, low-level microwave irradiation of rats. Bioelectromagnetics. 1992;13:469–496
  8. Christensen HC, Schuz J, Kosteljanetz M, et al. Cellular telephone use and risk of acoustic neuroma. Am J Epidemiol. 2004;159:277–283
  9. Christensen HC, Schuz J, Kosteljanetz M, et al. Cellular telephones and risk for brain tumors. Neurology. 2005;64:1189–1195
  10. Clegg LX, Feuer EJ, Midthune DN, et al. Impact of reporting delay and reporting error on cancer incidence rates and trends. J Natl Cancer Inst. 2002;94:1537–1545
  11. Diem E, Schwarz C, Adlkofer F, et al. Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro. Mutat Res. 2005;583:178–183
  12. Ferreri F, Curcio G, Pasqualetti P, et al. Mobile phone emissions and human brain excitability. Ann Neurol. 2006;60:188–196
  13. Hardell L, Carlberg M, Hansson Mild K. Use of cellular telephones and brain tumour risk in urban and rural areas. Occup Environ Med. 2005;62:390–394
  14. Hardell L, Carlberg M, Hansson Mild K. Pooled analysis of two case-control studies on the use of cellular and cordless telephones and the risk of benign brain tumours diagnosed during 1997–2003. Int J Oncol. 2006;28:509–518
  15. Hardell L, Carlberg M, Hansson Mild K. Methodological aspects of epidemiological studies on the use of mobile phones and their association with brain tumours. Open Environ J. 2008;2:54–61
  16. Hardell L, Carlberg M, Soderqvist F, et al. Meta-analysis of long-term mobile phone users and the association with brain tumours. Int J Oncology. 2008;32:1097–1103
  17. Hardell L, Hansson Mild K. Mobile phone use and risk of glioma in adults. Results are difficult to interpret because of limitations. Letter. BMJ. 2006;332:1035
  18. Hardell L, Hansson Mild K, Carlberg M. Pooled analysis of two case-control studies on use of cellular and cordless telephones and the risk for malignant brain tumours diagnosed in 1997–2003. Int Arch Occup Environ Health. 2006;79:630–639
  19. Hardell L, Hansson Mild K, Carlberg M, et al. Tumour risk associated with use of cellular telephones or cordless desktop telephones. World J Surg Oncol. 2006;4:74
  20. Hardell L, Sage C. Biological effects from electromagnetic field exposure and public exposure standards. Biomed Pharmacother. 2008;62:104–109
  21. Hoffman S, Propp JM, McCarthy BJ. Temporal trends in incidence of primary brain tumors in the United States, 1985-1999. Neuro Oncol. 2006;8:27–37
  22. Hyland GJ. Physics and biology of mobile telephony. Lancet. 2000;356:1833–1836
  23. Hepworth S, Shoemaker MJ, Muir KR, et al. Mobile phone use and risk of glioma in adults: case-control study. BMJ. 2006;332:883–887
  24. Inskip PD, Tarone RE, Hatch EE, et al. Cellular-telephone use and brain tumours. N Engl J Med. 2001;344:79–86
  25. Kan P, Simonsen SE, Lyon JL, et al. Cellular phone use and brain tumor: a meta-analysis. J Neurooncol. 2008;86:71–78
  26. Kheifets L, Repacholi M, Saunders R, et al. The sensitivity of children to electromagnetic fields. Pediatrics. 2005;116:303–313
  27. Khurana VG. Cell phone and DNA story overlooked studies. Letter. Science. 2008;322:1325
  28. Kundi M, Mild KJ, Hardell L, et al. Mobile telephones and cancer—a review of epidemiological evidence. J Toxicol Environ Health. 2004;7:351–384
  29. Lahkola A, Auvinen A, Raitanen J, et al. Mobile phone use and risk of glioma in 5 North European countries. Int J Cancer. 2007;120:1769–1775
  30. Lahkola A, Salminen T, Raitanen J, et al. Meningioma and mobile phone use—a collaborative case-control study in five North European countries. Int J Epidemiol. 2008;37:1304–1313
  31. Lai H, Singh NP. Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics. 1995;16:207–210
  32. Lai H, Singh NP. Melatonin and a spin-trap compound block radiofrequency electromagnetic radiation-induced DNA strand breaks in rat brain cells. Bioelectromagnetics. 1997;18:446–454
  33. Lee JS, Huang TQ, Kim TH, et al. Radiofrequency radiation does not induce stress response in human T-lymphocytes and rat primary astrocytes. Bioelectromagnetics. 2006;27:578–588
  34. Liu Y, Zhou K, Zhang H, et al. Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma. Hum Mutat. 2008;29:381–389
  35. Lonn S, Ahlbom A, Hall P, et al. Mobile phone use and the risk of acoustic neuroma. Epidemiology. 2004;15:653–659
  36. Lonn S, Ahlbom A, Hall P, et al. Long-term mobile phone use and brain tumor risk. Am J Epidemiol. 2005;161:526–535
  37. Lonn S, Forssen U, Vecchia P, et al. Output power levels from mobile phones in different geographical areas; implications for exposure assessment. Occup Environ Med. 2004;61:769–772
  38. Maisch D. Mobile phone use: it's time to take precautions. J Australas Coll Nutr Environ Med. 2001;20:3–10
  39. Malyapa RS, Ahern EW, Straube WL, et al. Measurement of DNA damage after exposure to electromagnetic radiation in the cellular phone communication frequency band (835.62 and 847.74 MHz). Radiation Res. 1997;148:618–627
  40. Milham S. Mobile phone use and risk of glioma in adults: case-control study. Letter to the Editor. Br J Cancer. 2006;94:1351
  41. Morgan LL. Cellular phones, cordless phones, and the risks of glioma and meningioma (INTERPHONE study group, Germany). Letter to the Editor. Am J Epidemiol. 2006;164:292–296
  42. Morgan LL. Mobile phone use and risk of glioma in adults. Study has many flaws. Letter. BMJ. 2006;332:1035
  43. Mashevich M, Folkman D, Kesar A, et al. Exposure of human peripheral blood lymphocytes to electromagnetic fields associated with cellular phones leads to chromosomal instability. Bioelectromagnetics. 2003;23:82–90
  44. Moulder JE, Foster KR, Erdreich LS, et al. Mobile phones, mobile phone base stations and cancer: a review. Int J Radiat Biol. 2005;81:189–203
  45. Muscat JE, Hinsvark M, Malkin M. Mobile telephones and rates of brain cancer. Neuroepidemiology. 2006;27:55–56
  46. Nylund R, Leszczynski D. Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent. Proteomics. 2006;6:4769–4780
  47. Panagopoulos DJ, Chavdoula ED, Nezis IP, et al. Cell death induced by GSM 900-MHz and DCS 1800-MHz mobile telephony radiation. Mutat Res. 2007;626:69–78
  48. Propp JM, McCarthy BJ, Davis FG, et al. Descriptive epidemiology of vestibular schwannomas. Neuro Oncol. 2006;8:1–11
  49. Rajaraman P, Wang SS, Rothman N, et al. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev. 2007;16:1655–1661
  50. Remondini D, Nylund R, Reivinen J, et al. Gene expression changes in human cells after exposure to mobile phone microwaves. Proteomics. 2006;6:4745–4754
  51. Repacholi MH, Basten A, Gebski V, et al. Lymphomas in Eu-Pim1 transgenic mice exposed to pulsed 900 MHz electromagnetic fields. Radiation Res. 1997;147:631–640
  52. Sadetzki S, Chetrit A, Jarus-Hakak A, et al. Cellular phone use and risk of benign and malignant parotid gland tumors—a nationwide case-control study. Am J Epidemiol. 2008;167:457–467
  53. Sakuma S, Komatsubara Y, Takeda H, et al. DNA strand breaks are not induced in human cells exposed to 2.1425 GHz band CW and W-CDMA modulated radiofrequency fields allocated to mobile radio base stations. Bioelectromagnetics. 2006;27:51–57
  54. Schoemaker MJ, Swerdlow AJ, Ahlbom A, et al. Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries. Br J Cancer. 2005;93:842–848
  55. Schuz J, Bohler E, Berg G, et al. Cellular phones, cordless phones, and the risks of glioma and meningioma (Interphone Study Group, Germany). Am J Epidemiol. 2006;163:512–520
  56. Schuz J, Jacobsen R, Olsen JH, et al. Cellular telephone use and cancer risk: Update of a nationwide Danish cohort. J Natl Cancer Inst. 2006;98:1707–1713
  57. Schwartzbaum JA, Ahlbom A, Lonn S, et al. An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. Cancer Epidemiol Biomarkers Prev. 2007;16:2448–2454
  58. Takashima Y, Hirose H, Koyama S, et al. Effects of continuous and intermittent exposure to RF fields with a wide range of SARs on cell growth, survival, and cell cycle distribution. Bioelectromagnetics. 2006;27:392–400
  59. Takebayashi T, Varsier N, Kikuchi Y, et al. Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour: a case-control study. Br J Cancer. 2008;98:652–659
  60. Thorlin T, Rouquette JM, Hamnerius Y, et al. Exposure of cultured astroglial and microglial brain cells to 900 MHz microwave radiation. Radiat Res. 2006;166:409–421
  61. Thuppal S, Propp JM, McCarthy BJ. Average years of potential life lost in those who have died from brain and CNS tumors in the USA. Neuroepidemiology. 2006;27:22–27
  62. Vijayalaxmi , Prihoda TJ. Genetic damage in mammalian somatic cells exposed to radiofrequency radiation: a meta-analysis of data from 63 publications (1990-2005). Radiat Res. 2008;169:561–574
  63. Vrijheid M, Armstrong BK, Bedard D, et al. Recall bias in the assessment of exposure to mobile phones. J Expo Sci Environ Epidemiol. 2008;1–13[Electronic publication ahead of print]
  64. Weisbrot D, Lin H, Ye L, Blank M, et al. Effects of mobile phone radiation on reproduction and development in Drosophila melanogaster. J Cell Biochem. 2003;89:48–55
  65. Wiart J, Hadjem A, Wong MF, et al. Analysis of RF exposure in the head tissues of children and adults. Phys Med Biol. 2008;53:3681–3695
  66. Yang Y, Jin X, Yan C, et al. Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia. Leuk Lymphoma. 2008;49:2344–2350
  67. Zhao TY, Zou SP, Knapp PE. Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes. Neurosci Lett. 2007;412:34–38
  68. Zook BC, Simmens SJ. The effects of 860 MHz radiofrequency radiation on the induction or promotion of brain tumours and other neoplasms in rats. Radiation Res. 2001;155:572–583

 There is no author conflict of interest, and no funding was requested or received for this review. The conclusions expressed in this article do not necessarily reflect those of the authors' affiliated institutions and employers.

PII: S0090-3019(09)00145-1

doi: 10.1016/j.surneu.2009.01.019

Surgical Neurology
Volume 72, Issue 3 , Pages 205-214 , September 2009