Surgical Neurology
Volume 72, Issue 6 , Pages 577-586 , December 2009

Preparing the ethical future of deep brain stimulation

  • Emily Bell, PhD

      Affiliations

    • Neuroethics Research Unit, Institut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada
    • ,
  • Ghislaine Mathieu, MA

      Affiliations

    • Neuroethics Research Unit, Institut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada
    • ,
  • Eric Racine, PhD

      Affiliations

    • Neuroethics Research Unit, Institut de recherches cliniques de Montréal (IRCM), Montréal, QC, Canada
    • Department of Medicine, Université de Montréal, Montréal, QC, Canada
    • Department of Social and Preventive Medicine, Université de Montréal, Montréal, QC, Canada
    • Department of Neurology and Neurosurgery & Biomedical Ethics Unit, McGill University, Montréal, QC, Canada
    • Corresponding Author InformationCorresponding author. Tel.: +1 514 987 5723; fax: +1 514 987 5763.

Received 18 July 2008 ,Accepted 24 March 2009.

References 

  1. Agid Y, Schupbach M, Gargiulo M, et al. Neurosurgery in Parkinson's disease: the doctor is happy, the patient less so?. J Neural Transm Suppl. 2006;70:409–414
  2. Amick MM, Grace J. Deep brain stimulation surgery for Parkinson's disease: the role of neuropsychological assessment. Med Health R I. 2006;89:130–133
  3. Bell E, Racine E. Ethics in deep brain stimulation in alcohol dependence. (Comment on “Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?”). J Neurol Neurosurg Psychiatry e-Letters. 2007;Nov 21 (electronic publication)
  4. Benabid AL. What the future holds for deep brain stimulation. Expert Rev Med Devices. 2007;4:895–903
  5. Burkhard PR, Vingerhoets FJ, Berney A, et al. Suicide after successful deep brain stimulation for movement disorders. Neurology. 2004;63:2170–2172
  6. Cassels A, Hughes MA, Cole C, et al. Drugs in the news: an analysis of Canadian newspaper coverage of new prescription drugs. Cmaj. 2003;168:1133–1137
  7. Castelli L, Perozzo P, Zibetti M, et al. Chronic deep brain stimulation of the subthalamic nucleus for Parkinson's disease: effects on cognition, mood, anxiety and personality traits. Eur Neurol. 2006;55:136–144
  8. Contarino MF, Daniele A, Sibilia AH, et al. Cognitive outcome 5 years after bilateral chronic stimulation of subthalamic nucleus in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2007;78:248–252
  9. Davis H. Currents of hope. Buffalo News. Buffalo, 2002, A1.
  10. Deuschl G, Schade-Brittinger C, Krack P, et al. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med. 2006;355:896–908
  11. Diamond A. Problems with deep brain stimulation devices referred to private practice for follow up. Parkinsonism Relat Disord. 2007;13:520–523
  12. Diefenbach GJ, Diefenbach D, Baumeister A, et al. Portrayal of lobotomy in the popular press: 1935-1960. J Hist Neurosci. 1999;8:60–69
  13. Drapier D, Drapier S, Sauleau P, et al. Does subthalamic nucleus stimulation induce apathy in Parkinson's disease?. J Neurol. 2006;253:1083–1091
  14. Eitan RBL. Nonpharmacological, somatic treatments of depression: electroconvulsive therapy and novel brain stimulation modalities. Dialogues Clin Neurosci. 2006;8:241–258
  15. Emanuel EJ, Emanuel LL. Four models of the physician-patient relationship. JAMA. 1992;267:2221–2226
  16. Fins JJ. A proposed ethical framework for international cognitive neuroscience: a consideration of deep brain stimulation in impaired consciousness. Neurol Res. 2000;22:273–278
  17. Fins JJ. Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access. Nat Rev Neurosci. 2003;4:323–327
  18. Fins JJ. From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurg Clin N Am. 2003;14:303–319ix-x
  19. Fins JJ, Rezai AR Greenberg BD. Psychosurgery: avoiding an ethical redux while advancing a therapeutic future. Neurosurgery. 2006;59:713–716
  20. Fisher RS, Handforth A. Reassessment: vagus nerve stimulation for epilepsy. Neurology. 1999;53:666–669
  21. Fraix V, Houeto JL, Lagrange C, et al. Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2006;77:443–449
  22. Fraraccio M, Ptito A, Sadikot A, et al. Absence of cognitive deficits following deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Arch Clin Neuropsychol. 2008;23:399–408
  23. Funkiewiez A, Ardouin C, Caputo E, et al. Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2004;75:834–839
  24. Gabriels L, Cosyns P, Nuttin B, et al. Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: psychopathological and neuropsychological outcome in three cases. Acta Psychiatr Scand. 2003;107:275–282
  25. Green AL, Joint C, Sethi H, et al. Cost analysis of unilateral and bilateral pallidotomy for Parkinson's disease. J Clin Neurosci. 2004;11:829–834
  26. Greenberg BD. Update on deep brain stimulation. J ECT. 2002;18:193–196
  27. Grill WM. Safety considerations for deep brain stimulation: review and analysis. Expert Rev Med Devices. 2005;2:409–420
  28. Hamani C, McAndrews MP, Cohn M, et al. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol. 2008;63:119–123
  29. Holloway RG, Ringel SP, Bernat JL, et al. US neurologists: attitudes on rationing. Neurology. 2000;55:1492–1497
  30. Houeto JL, Mesnage V, Mallet L, et al. Behavioural disorders, Parkinson's disease and subthalamic stimulation. J Neurol Neurosurg Psychiatry. 2002;72:701–707
  31. Illes J, Blakemore C, Hansson MG, et al. International perspectives on engaging the public in neuroscience. Nat Rev Neurosci. 2005;6:977–982
  32. Illes J, Kirschen MP, Edwards E, et al. Incidental findings in brain imaging research. Science. 2006;311:783–784
  33. Illes J, Rosen A, Greicius M, et al. Prospects for prediction: ethics analysis of neuroimaging in Alzheimer's disease. Ann N Y Acad Sci. 2007;1097:278–295
  34. Kern DS, Kumar R. Deep brain stimulation. Neurologist. 2007;13:237–252
  35. Kim SYH. Evidence-based ethics for neurology and psychiatry research. NeuroRx. 2004;1:372–377
  36. Kopell BH, Greenberg B, Rezai AR. Deep brain stimulation for psychiatric disorders. J Clin Neurophysiol. 2004;21:51–67
  37. Krack P, Batir A, Van Blercom N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med. 2003;349:1925–1934
  38. Kubu CS, Ford PJ. Ethics in the clinical application of neural implants. Camb Q Healthc Ethics. 2007;16:317–321
  39. Kuehn BM. Scientists probe deep brain stimulation: some promise for brain injury, psychiatric illness. Jama. 2007;298:2249–2251
  40. Kuhn J, Lenartz D, Huff W, et al. Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?. J Neurol Neurosurg Psychiatry. 2007;78:1152–1153
  41. Lang AE, Widner H. Deep brain stimulation for Parkinson's disease: patient selection and evaluation. Mov Disord. 2002;17(Suppl 3):S94–S101
  42. Larson PS. Deep brain stimulation for psychiatric disorders. Neurotherapeutics. 2008;5:50–58
  43. Lauber C, Nordt C, Falcato L, et al. Can a seizure help? The public's attitude toward electroconvulsive therapy. Psychiatry Res. 2005;134:205–209
  44. Lim D, Sanderson K, Andrews G. Lost productivity among full-time workers with mental disorders. J Ment Health Policy Econ. 2000;3:139–146
  45. Lopes M, Meningaud JP, Behin A, et al. Consent: a Cartesian ideal? Human neural transplantation in Parkinson's disease. Med Law. 2003;22:63–71
  46. Lozano AM, Hamani C. The future of deep brain stimulation. J Clin Neurophysiol. 2004;21:68–69
  47. Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45:651–660
  48. Meissner W, Schreiter D, Volkmann J, et al. Deep brain stimulation in late stage Parkinson's disease: a retrospective cost analysis in Germany. J Neurol. 2005;252:218–223
  49. Milby AH, Halpern CH, Baltuch GH. Vagus nerve stimulation for epilepsy and depression. Neurotherapeutics. 2008;5:75–85
  50. Miller FG, Fins JJ. Protecting human subjects in brain research: a pragmatic perspective. In:  Illes J editors. Neuroethics: defining the issues in theory, practice, and policy. Oxford: Oxford University Press; 2006;p. 123–140
  51. Morgante L, Morgante F, Moro E, et al. How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire. Parkinsonism Relat Disord. 2007;13:528–531
  52. Munce SE, Stansfeld SA, Blackmore ER, et al. The role of depression and chronic pain conditions in absenteeism: results from a national epidemiologic survey. J Occup Environ Med. 2007;49:1206–1211
  53. Nandi D, Aziz TZ. Deep brain stimulation in the management of neuropathic pain and multiple sclerosis tremor. J Clin Neurophysiol. 2004;21:31–39
  54. Nuttin B, Gybels J, Cosyns P, et al. Deep brain stimulation for psychiatric disorders. Neurosurg Clin N Am. 2003;14:xv–xvi
  55. Okun MS, Foote KD. A mnemonic for Parkinson disease patients considering DBS: a tool to improve perceived outcome of surgery. Neurologist. 2004;10:290
  56. Pahwa R, Lyons KE, Wilkinson SB, et al. Long-term evaluation of deep brain stimulation of the thalamus. J Neurosurg. 2006;104:506–512
  57. Racine E, Bar-Ilan O, Illes J. Brain imaging: a decade of coverage in the print media. Sci Commun. 2006;28:122–142
  58. Racine E, Gareau I, Doucet H, et al. Hyped biomedical science or uncritical reporting? Press coverage of genomics (1992-2001) in Québec. Soc Sci Med. 2006;62:1278–1290
  59. Racine E, Van der Loos HZA, Illes J. Internet marketing of neuroproducts: new practices and healthcare policy challenges. Camb Q Healthc Ethics. 2007;16:181–194
  60. Racine E, Waldman S, Palmour N, et al. Currents of hope: neurostimulation techniques in US and UK print media. Camb Q Healthc Ethics. 2007;16:314–318
  61. Rezai AR, Kopell BH, Gross RE, et al. Deep brain stimulation for Parkinson's disease: surgical issues. Mov Disord. 2006;21(Suppl 14):S197–S218
  62. Rodriguez RL, Fernandez HH, Haq I, et al. Pearls in patient selection for deep brain stimulation. Neurologist. 2007;13:253–260
  63. Saint-Cyr JA, Trepanier LL. Neuropsychologic assessment of patients for movement disorder surgery. Mov Disord. 2000;15:771–783
  64. Saxena S, Sharan P Saraceno B. Budget and financing of mental health services: baseline information on 89 countries from WHO's project atlas. J Ment Health Policy Econ. 2003;6:135–143
  65. Saxena S, Thornicroft G, Knapp M, et al. Resources for mental health: scarcity, inequity, and inefficiency. Lancet. 2007;370:878–889
  66. Schupbach M, Gargiulo M, Welter ML, et al. Neurosurgery in Parkinson disease: a distressed mind in a repaired body?. Neurology. 2006;66:1811–1816
  67. Schupbach WM, Chastan N, Welter ML, et al. Stimulation of the subthalamic nucleus in Parkinson's disease: a 5 year follow up. J Neurol Neurosurg Psychiatry. 2005;76:1640–1644
  68. Schwalb JM, Hamani C. The history and future of deep brain stimulation. Neurotherapeutics. 2008;5:3–13
  69. Schwartz LM, Woloshin S, Baczek L. Media coverage of scientific meetings: too much, too soon?. JAMA. 2002;287:2859–2863
  70. Shorter E, Healy D. In: Shock Therapy: A history of electroconvulsive treatment in mental illness. Toronto: University of Toronto Press; 2007;p. 382
  71. Soulas T, Gurruchaga JM, Palfi S, et al. Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson's disease. J Neurol Neurosurg Psychiatry. 2008;79:952–954
  72. Staab JP, Datto CJ, Weinrieb RM, et al. Detection and diagnosis of psychiatric disorders in primary medical care settings. Med Clin North Am. 2001;85:579–596
  73. Stein R. In: The potential of ‘brain pacemakers’: implanted devices may alter treatment of many disorders. Washington: Washington Post; 2004;p. A1–A6
  74. Temel Y, Kessels A, Tan S, et al. Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review. Parkinsonism Relat Disord. 2006;12:265–272
  75. Tir M, Devos D, Blond S, et al. Exhaustive, one-year follow-up of subthalamic nucleus deep brain stimulation in a large, single-center cohort of parkinsonian patients. Neurosurgery. 2007;61:297–304[discussion 304-5]
  76. Valldeoriola F, Morsi O, Tolosa E, et al. Prospective comparative study on cost-effectiveness of subthalamic stimulation and best medical treatment in advanced Parkinson's disease. Mov Disord. 2007;22:2183–2191
  77. Volkmann J. Deep brain stimulation for the treatment of Parkinson's disease. J Clin Neurophysiol. 2004;21:6–17
  78. Wang PS, Simon G, Kessler RC. The economic burden of depression and the cost-effectiveness of treatment. Int J Methods Psychiatr Res. 2003;12:22–33
  79. Woloshin S, Schwartz LM. Media reporting on research presented at scientific meetings: more caution needed. Med J Aust. 2006;184:576–580
  80. Wolpe PR, Ford PJ, Harhay M. Bioethical issues in deep brain stimulation. In:  Baltuch G,  Stern MB editor. Deep brain stimulation for Parkinson's disease. (Informa) NY, London: Taylor and Francis; 2007;p. 323–338
  81. Zhang M, Rost KM, Fortney JC, et al. A community study of depression treatment and employment earnings. Psychiatr Serv. 1999;50:1209–1213
  82. Zuckerman D. Hype in health reporting: “checkbook science” buys distortion of medical news. Int J Health Serv. 2003;33:383–389

PII: S0090-3019(09)00285-7

doi: 10.1016/j.surneu.2009.03.029

Surgical Neurology
Volume 72, Issue 6 , Pages 577-586 , December 2009

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